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Somatization

MedGen UID:
57446
•Concept ID:
C0149779
•
Mental or Behavioral Dysfunction

Definition

The conversion of mental experiences or states into physical symptoms. [from NCI]

Professional guidelines

PubMed

Management of bloating.
Serra J
Neurogastroenterol Motil 2022 Mar;34(3):e14333. Epub 2022 Feb 10 doi: 10.1111/nmo.14333. PMID: 35143108
Short-term psychodynamic psychotherapy for functional somatic disorders: A systematic review and meta-analysis of within-treatment effects.
Abbass A, Lumley MA, Town J, Holmes H, Luyten P, Cooper A, Russell L, Schubiner H, De Meulemeester C, Kisely S
J Psychosom Res 2021 Jun;145:110473. Epub 2021 Mar 26 doi: 10.1016/j.jpsychores.2021.110473. PMID: 33814192
Different Clinical Expression of Anxiety Disorders in Children and Adolescents: Assessment and Treatment.
Pop-Jordanova N
Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2019 May 1;40(1):5-40. doi: 10.2478/prilozi-2019-0001. PMID: 31152643

Recent clinical studies

Etiology

Fatigue and somatization in shift-workers: Effects of depression and sleep.
Seo JW, Lee J, Jeon S, Hwang Y, Kim J, Lee S, Kim SJ
J Psychosom Res 2023 Oct;173:111467. Epub 2023 Aug 17 doi: 10.1016/j.jpsychores.2023.111467. PMID: 37619432
The Amplification of Symptoms in the Medically Ill.
Barsky AJ, Silbersweig DA
J Gen Intern Med 2023 Jan;38(1):195-202. Epub 2022 Jul 12 doi: 10.1007/s11606-022-07699-8. PMID: 35829874Free PMC Article
Psychological Interventions for Irritable Bowel Syndrome.
Surdea-Blaga T, Baban A, Nedelcu L, Dumitrascu DL
J Gastrointestin Liver Dis 2016 Sep;25(3):359-66. doi: 10.15403/jgld.2014.1121.253.ibs. PMID: 27689201
Somatoform disorders.
Oyama O, Paltoo C, Greengold J
Am Fam Physician 2007 Nov 1;76(9):1333-8. PMID: 18019877
A systematic review of psychological factors as predictors of chronicity/disability in prospective cohorts of low back pain.
Pincus T, Burton AK, Vogel S, Field AP
Spine (Phila Pa 1976) 2002 Mar 1;27(5):E109-20. doi: 10.1097/00007632-200203010-00017. PMID: 11880847

Diagnosis

The Amplification of Symptoms in the Medically Ill.
Barsky AJ, Silbersweig DA
J Gen Intern Med 2023 Jan;38(1):195-202. Epub 2022 Jul 12 doi: 10.1007/s11606-022-07699-8. PMID: 35829874Free PMC Article
Psychological Interventions for Irritable Bowel Syndrome.
Surdea-Blaga T, Baban A, Nedelcu L, Dumitrascu DL
J Gastrointestin Liver Dis 2016 Sep;25(3):359-66. doi: 10.15403/jgld.2014.1121.253.ibs. PMID: 27689201
Somatoform disorders.
Oyama O, Paltoo C, Greengold J
Am Fam Physician 2007 Nov 1;76(9):1333-8. PMID: 18019877
Somatization and conversion disorder.
Hurwitz TA
Can J Psychiatry 2004 Mar;49(3):172-8. doi: 10.1177/070674370404900304. PMID: 15101499
Somatization and depression.
Lipowski ZJ
Psychosomatics 1990 Winter;31(1):13-21. doi: 10.1016/S0033-3182(90)72212-8. PMID: 2405448

Therapy

Efficacy and Safety of Aripiprazole in Borderline Personality Disorder: A Systematic Review.
Valdivieso-Jiménez G, Pino-Zavaleta DA, Campos-Rodriguez SK, Ortiz-Saavedra B, Fernández MF, Benites-Zapata VA
Psychiatr Q 2023 Dec;94(4):541-557. Epub 2023 Aug 11 doi: 10.1007/s11126-023-10045-8. PMID: 37566261
Effect of brexanolone on depressive symptoms, anxiety, and insomnia in women with postpartum depression: Pooled analyses from 3 double-blind, randomized, placebo-controlled clinical trials in the HUMMINGBIRD clinical program.
Epperson CN, Rubinow DR, Meltzer-Brody S, Deligiannidis KM, Riesenberg R, Krystal AD, Bankole K, Huang MY, Li H, Brown C, Kanes SJ, Lasser R
J Affect Disord 2023 Jan 1;320:353-359. Epub 2022 Sep 30 doi: 10.1016/j.jad.2022.09.143. PMID: 36191643
Short-term psychodynamic psychotherapy for functional somatic disorders: A systematic review and meta-analysis of within-treatment effects.
Abbass A, Lumley MA, Town J, Holmes H, Luyten P, Cooper A, Russell L, Schubiner H, De Meulemeester C, Kisely S
J Psychosom Res 2021 Jun;145:110473. Epub 2021 Mar 26 doi: 10.1016/j.jpsychores.2021.110473. PMID: 33814192
Probiotic Bifidobacterium longum NCC3001 Reduces Depression Scores and Alters Brain Activity: A Pilot Study in Patients With Irritable Bowel Syndrome.
Pinto-Sanchez MI, Hall GB, Ghajar K, Nardelli A, Bolino C, Lau JT, Martin FP, Cominetti O, Welsh C, Rieder A, Traynor J, Gregory C, De Palma G, Pigrau M, Ford AC, Macri J, Berger B, Bergonzelli G, Surette MG, Collins SM, Moayyedi P, Bercik P
Gastroenterology 2017 Aug;153(2):448-459.e8. Epub 2017 May 5 doi: 10.1053/j.gastro.2017.05.003. PMID: 28483500
Somatoform disorders.
Oyama O, Paltoo C, Greengold J
Am Fam Physician 2007 Nov 1;76(9):1333-8. PMID: 18019877

Prognosis

Characterization of pain and somatization and its relationship with psychopathology in early onset psychosis.
van der Heijden H, Goldman M, Ray A, Golden E, Petty CR, Deaso E, Hojlo M, Sethna N, Glahn DC, Gonzalez-Heydrich J, Upadhyay J
J Psychiatr Res 2024 Nov;179:77-82. Epub 2024 Sep 7 doi: 10.1016/j.jpsychires.2024.09.006. PMID: 39260111Free PMC Article
Key psychosocial issues in medical care.
Fava GA, Patierno C, Sonino N, Cosci F
Acta Psychiatr Scand 2024 May;149(5):368-377. Epub 2024 Feb 1 doi: 10.1111/acps.13667. PMID: 38303125
Psychological inflexibility and somatization in nonepileptic attack disorder.
Cullingham T, Kirkby A, Eccles FJR, Sellwood W
Epilepsy Behav 2020 Oct;111:107155. Epub 2020 Jun 17 doi: 10.1016/j.yebeh.2020.107155. PMID: 32563053
Psychological Interventions for Irritable Bowel Syndrome.
Surdea-Blaga T, Baban A, Nedelcu L, Dumitrascu DL
J Gastrointestin Liver Dis 2016 Sep;25(3):359-66. doi: 10.15403/jgld.2014.1121.253.ibs. PMID: 27689201
A systematic review of psychological factors as predictors of chronicity/disability in prospective cohorts of low back pain.
Pincus T, Burton AK, Vogel S, Field AP
Spine (Phila Pa 1976) 2002 Mar 1;27(5):E109-20. doi: 10.1097/00007632-200203010-00017. PMID: 11880847

Clinical prediction guides

Characterization of pain and somatization and its relationship with psychopathology in early onset psychosis.
van der Heijden H, Goldman M, Ray A, Golden E, Petty CR, Deaso E, Hojlo M, Sethna N, Glahn DC, Gonzalez-Heydrich J, Upadhyay J
J Psychiatr Res 2024 Nov;179:77-82. Epub 2024 Sep 7 doi: 10.1016/j.jpsychires.2024.09.006. PMID: 39260111Free PMC Article
Effects of Anxious Depression on Antidepressant Treatment Response.
Hampf C, Scherf-Clavel M, Weiß C, Klüpfel C, Stonawski S, Hommers L, Lichter K, Erhardt-Lehmann A, Unterecker S, Domschke K, Kittel-Schneider S, Menke A, Deckert J, Weber H
Int J Mol Sci 2023 Dec 5;24(24) doi: 10.3390/ijms242417128. PMID: 38138957Free PMC Article
Fatigue and somatization in shift-workers: Effects of depression and sleep.
Seo JW, Lee J, Jeon S, Hwang Y, Kim J, Lee S, Kim SJ
J Psychosom Res 2023 Oct;173:111467. Epub 2023 Aug 17 doi: 10.1016/j.jpsychores.2023.111467. PMID: 37619432
Psychological inflexibility and somatization in nonepileptic attack disorder.
Cullingham T, Kirkby A, Eccles FJR, Sellwood W
Epilepsy Behav 2020 Oct;111:107155. Epub 2020 Jun 17 doi: 10.1016/j.yebeh.2020.107155. PMID: 32563053
Psychological Interventions for Irritable Bowel Syndrome.
Surdea-Blaga T, Baban A, Nedelcu L, Dumitrascu DL
J Gastrointestin Liver Dis 2016 Sep;25(3):359-66. doi: 10.15403/jgld.2014.1121.253.ibs. PMID: 27689201

Recent systematic reviews

Efficacy and Safety of Aripiprazole in Borderline Personality Disorder: A Systematic Review.
Valdivieso-Jiménez G, Pino-Zavaleta DA, Campos-Rodriguez SK, Ortiz-Saavedra B, Fernández MF, Benites-Zapata VA
Psychiatr Q 2023 Dec;94(4):541-557. Epub 2023 Aug 11 doi: 10.1007/s11126-023-10045-8. PMID: 37566261
Short-term psychodynamic psychotherapy for functional somatic disorders: A systematic review and meta-analysis of within-treatment effects.
Abbass A, Lumley MA, Town J, Holmes H, Luyten P, Cooper A, Russell L, Schubiner H, De Meulemeester C, Kisely S
J Psychosom Res 2021 Jun;145:110473. Epub 2021 Mar 26 doi: 10.1016/j.jpsychores.2021.110473. PMID: 33814192
Psychiatric disorders in women with polycystic ovary syndrome: a systematic review and meta-analysis.
Brutocao C, Zaiem F, Alsawas M, Morrow AS, Murad MH, Javed A
Endocrine 2018 Nov;62(2):318-325. Epub 2018 Jul 31 doi: 10.1007/s12020-018-1692-3. PMID: 30066285
The Patient Health Questionnaire Somatic, Anxiety, and Depressive Symptom Scales: a systematic review.
Kroenke K, Spitzer RL, Williams JB, Löwe B
Gen Hosp Psychiatry 2010 Jul-Aug;32(4):345-59. Epub 2010 May 7 doi: 10.1016/j.genhosppsych.2010.03.006. PMID: 20633738
A systematic review of psychological factors as predictors of chronicity/disability in prospective cohorts of low back pain.
Pincus T, Burton AK, Vogel S, Field AP
Spine (Phila Pa 1976) 2002 Mar 1;27(5):E109-20. doi: 10.1097/00007632-200203010-00017. PMID: 11880847

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